The rapid growth of mobile applications, the popularity of the Android system and its openness have attracted many hackers and even criminals, who are creating lots of Android malware. However, the current methods of Android malware detection need a lot of time in the feature engineering phase. Furthermore, these models have the defects of low detection rate, high complexity, and poor practicability, etc. We analyze the Android malware samples, and the distribution of malware and benign software in application programming interface (API) calls, permissions, and other attributes. We classify the software’s threat levels based on the correlation of features. Then, we propose deep neural networks and convolutional neural networks with ensemble learning (DCEL), a new classifier fusion model for Android malware detection. First, DCEL preprocesses the malware data to remove redundant data, and converts the one-dimensional data into a two-dimensional gray image. Then, the ensemble learning approach is used to combine the deep neural network with the convolutional neural network, and the final classification results are obtained by voting on the prediction of each single classifier. Experiments based on the Drebin and Malgenome datasets show that compared with current state-of-art models, the proposed DCEL has a higher detection rate, higher recall rate, and lower computational cost.